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In Fallout 76, knowing your enemy isn’t just about survival—it’s also a smart way to turn every encounter into profit. Whether you’re farming materials, seeking rare Fallout 76 Items, or simply trying to Buy Fallout 76 Caps with your loot indirectly, exploiting enemy weaknesses makes everything more efficient. Here are 18 enemies with specific vulnerabilities you can take advantage of for a smoother, more profitable journey through Appalachia.

1. Scorched – Weak to Fire and PlasmaScorched enemies take extra damage from fire-based weapons and plasma attacks. Flamers and plasma guns tear through them quickly, saving ammo and time.

2. Ghouls – Weak to Energy WeaponsFeral Ghouls fall fast when hit with laser rifles or gamma guns. Target them in groups, especially in locations like Morgantown High School for easy loot.

3. Super Mutants – Weak to Ballistic HeadshotsHigh-accuracy rifles and V.A.T.S.-focused builds shine here. Aim for the head to reduce armor waste and maximize junk yields.

4. Mirelurks – Weak at the Face and UnderbellySkip the shell; go for the face. Use shotguns or high-impact weapons, and farm locations like Dolly Sods for meat and materials.

5. Deathclaws – Weak to Crippling and Limb DamageUse weapons with limb damage effects. Crippling a Deathclaw stops it from rushing you and allows for safer looting of their high-value remains.

6. Wendigos – Weak to Explosives and Crowd ControlDon’t let them get close. Grenades and explosive shotguns keep Wendigos off you and make their loot runs faster and safer.

7. Radtoads – Weak to Precision WeaponsThese oversized amphibians are erratic, but their heads are big targets. Snipers or quick V.A.T.S. usage can down them fast and net their glands for crafting.

8. Honey Beasts – Weak Behind the HiveTarget the area behind the honeycomb for increased damage. Farming these can yield valuable honey and crafting parts.

9. Robots – Weak to EMP and Energy DrainPulse grenades and Tesla weapons are perfect for Sentry Bots and Assaultrons. Their scrap yields are ideal for crafting and resale.

10. Cultists – Weak to Armor-Piercing AmmoOften lightly armored, cultists go down quickly with piercing rounds. Their camps are good spots to farm lower-tier Fallout 76 Items for resale.

11. Floaters – Weak to Fire and Area DamageThey’re soft-skinned and volatile. Use area weapons like Molotovs or auto-grenade launchers to quickly clear groups.

12. Blood Eagles – Weak to Stealth TakedownsGreat targets for stealth builds. Farm their stashes and armor sets, which sell well at vendors and player camps.

13. Mothman Cultists – Weak to Incendiary RoundsSet them ablaze with fire-based ammo. They carry high-value religious Fallout 76 Items that players often collect.

14. Snallygasters – Weak to Limb TargetingSimilar to Deathclaws, crippling their legs reduces threat level. Their acid and glands are valuable for crafting and selling.

15. Grafton Monster – Weak to Cold-Based WeaponsCryo-based weapons or effects slow it dramatically, giving you time to kite and farm this mini-boss more easily.

16. Sheep Squatch – Weak to ExplosivesThese tanky enemies take longer to kill. Mines and grenades help reduce the time investment, especially in events like Free Range.

17. Megasloths – Weak to Fire and StealthEasily ambushed due to their slow movement. Use stealth crit builds to farm their hides and valuable meat without much resistance.

18. Legendary Enemies – Weak to Status EffectsRadiation, poison, bleed—status effect builds melt legendaries quickly, making legendary item farming far more efficient.

Mastering these weaknesses not only helps you dominate Appalachia but also allows you to farm, craft, and sell more effectively. If you're short on time or looking to boost your income, many players choose to Buy Fallout 76 Caps to get ahead, but leveraging enemy vulnerabilities is a more satisfying—and sustainable—way to profit.

Whether you're grinding events or just roaming the wasteland, keep these weaknesses in mind. Turning battles into business is what separates savvy survivors from struggling scavengers in Fallout 76.